報(bào)告題目：Engineering the Molecular Dynamics of Polymeric Biomaterials for Regulating Cellular Functions
報(bào)告人：邊黎明副教授
報(bào)告時(shí)間：2018年11月8日（星期四）下午17:00-18:00
報(bào)告地點(diǎn)：友誼校區(qū)老圖書館401室
邀請(qǐng)人：李鵬教授
報(bào)告簡(jiǎn)介：The dynamic properties of polymeric biomaterials at molecular level impart significant impact on the cellular behaviors. Developing tunable molecularly-dynamic polymeric biomaterials is highly instrumental to the fundamental investigation on cellular responses to the dynamic cues in extracellular environment. For example, cellular adhesion is controlled by the dynamic ligation process of surface receptors, such as integrin, to adhesive motifs, such as Arg-Gly-Asp (RGD). Remote control of adhesive ligand presentation on biomaterial surfaces can offer benefits in regulating cell-implant interactions, thereby immune responses or tissue regeneration in vivo. Herein we present a strategy for modulating nanoscale ligand oscillations on 2D biomaterial substrates by adjusting the frequency of an oscillating magnetic field to modulate the adhesion and specialization of stem cells and macrophages. To investigate 3D culture of cells in hydrogels with dynamic network structures, we have developed a series of dynamic hydrogels based on reversible crosslinks with unique properties such as resilient mechanical property, fast relaxation, self-healing, bioadhesiveness, injectability, and promoting recruitment of endogenous cells. These hydrogel properties are not only desirable for potential clinical applications of these hydrogels but also useful for studying the effect of microenvironmental mechanical cues on stem cell behaviors.
報(bào)告人簡(jiǎn)介：邊黎明，香港中文大學(xué)生物醫(yī)學(xué)工程系，副教授。邊教授分別于2002年及2004年在新加坡國(guó)立大學(xué)獲得本科學(xué)士及生物工程碩士學(xué)位。2004年赴美哥倫比亞大學(xué)生物醫(yī)學(xué)工程學(xué)系繼續(xù)攻讀博士學(xué)位。2009年獲博士學(xué)位后，在賓夕法尼亞大學(xué)生物工程學(xué)系進(jìn)行博士后研究。2012年夏開始就職于香港中文大學(xué)。邊教授研究的主要方向是生物支架材料及納米生物材料的設(shè)計(jì)及在干細(xì)胞組織工程方面的應(yīng)用。具體的研究方向有仿生生物材料的設(shè)計(jì)開發(fā)，細(xì)胞微環(huán)境信息對(duì)干細(xì)胞行為的影響，多功能水凝膠的設(shè)計(jì)，納米結(jié)構(gòu)用于生物配體微觀呈遞，干細(xì)胞組織工程等。邊教授的科研成果發(fā)表在PNAS，Biomaterials，Nano Letters，Advanced Functional Materials，JACS，ACS Nano，Advanced Materials，Advanced Science，Macromolecules，Chemistry of Materials等學(xué)術(shù)期刊雜志。
